Tuesday, 21 August 2018

Organ Testing Device


Organ Testing Device

Medical advances are taking off now more than ever relatable, innovative but realistic. It has the potential to change all of healthcare. Most serious problems we are facing in medicine industries is about drugs. We all take drugs in our life in some occasions and many peoples they are absolutely necessary.


Have you ever wondered how much money and time it takes to develop such drugs? Have you guys ever thought about it? We give you an example of a very common drug name Lipitor. A very common drug used by 60% U.S peoples for making this medicine. It takes 1 billion money and 12 years for discovering this drug. Isn’t a lot of money and time for producing just one drug. This is not a problem for this particular drug, but this is a problem for the entire pharmaceutical industry. So today developing one successful drug means a lot of time and money and this problem is getting worst so pharmaceutical companies spending more and more money every year to develop new drugs. But the number of successful drugs decline steadily over the past to decades and this productivity crisis becoming major threats to the pharmaceutical industry. We can say that we are failing in delivering new drugs to clinics. So, this is the time to really think to reverse this undesirable trend. This is a very big and serious problem. According to research high cause in a long time for drug development are mainly failure of drug in clinical trial and to minimize because risk of failure drug developer actually tries to protect drug in human before clinical trials and testing drugs on human surrogates in preclinical stage, for example, one of the traditional models is very simple in this technique cell from the human body and grow them on a plastic dish and test drugs on them. But if you think about it this is just a strange, unnatural, incompatible environment to these cells as compared to the environment in the complex human body.

As a result, we cannot get an accurate result so secondly, these drugs tested on an animal body like mice monkey etc. but an animal like mice cannot represent a tissue similar to the human body because their biology is completely different from us. That’s why animal testing fails most of the time to that drugs. So, solving these problems can we develop better more realistic and protective model of the human body. So, the scientist comes we the unique solution to this problem by the ORGAN TESTING DEVICE

These microchips served as models of human organs. These microchips are composed of a clear flexible polymer about the size of a computer memory stick that contains hollow microfluidic channels lined by living human organ-specific cell interfaced with a human endothelial cell-lined artificial vasculature and mimic to the physical environment of living organs including breathing motions in lung and peristalsis like deformations in the intestine. Organ chips present an ideal micro-environment to study molecular and cellular scale activities that underline human organ functions and mimic human-specific diseases state like the alveolar-capillary interface and blood-brain barrier. Organ chips are now being explored worldwide as tools for accurately predicting drug efficiency and toxicity. The WYSS institute is currently seeking a partner in their ongoing research and development. So, friends do you think whether our India need a similar technology or not? Whatever the talk is done for the good of the animals and for their safety, should we stop doing all this or should we really raise step so that they can live peacefully as we do?

These multi-organ chip could also allow to test out a number of drugs in pre-clinical testing without ethical limitations and could even replace one day long, costly and ethically tricky animal testing.

Finally, organ-on-chips adapted to individualized medicine could allow cultivating human on a chip with each patient’s stem cell. It could allow creating and test out the effect of anti-aging treatments on organs-on-chip specific to each patient before treatment.

Organ-on-a-chip (device)

AN Oxford University spin-out has launched a tool (Device) that permits scientists to check potential medicine in standard cell culture labs while not the necessity for animal models. The technology, that has been launched in Europe, the US and Asia, may gain advantage analysis into treatments for diseases like cancer and Alzheimer’s.

PhysioMimix, An organ-on-a-chip device, has open-well plates within which cells or pre-formed tissues will be placed so as to mimic a spread human organs and tissues from liver, lungs, and gut to heart, urinary organ, and brain tissues. In addition multiple devices will be coupled victimization little, fluid-filled channels to review however many organs move with each other and reply to stimuli. The technology was developed at Vanderbilt University and MIT, United Nations agency commissioned it to CN Bio.

How Organic Device Works
  • Compartments made up of a plastic block;
  • Passages for fluid to maneuver (as a cardiovascular system does) between the compartments;
  • A water reservoir to limit fluid evaporation; and,
  • Ability to watch the flow of molecular exchanges and drug distribution.

Essentially, exploitation the Massachusetts Institute of Technology device, a drug may be introduced to 1 organ, processed unremarkably, and so passed to different organs for process and use in different ways in which, TechCrunch summarized.

The physiome-on-a-chip system (above schematic) contains bioengineered devices that nurture several interconnected 3D MPSs representing such useful behaviors of every organ of interest, designed to capture essential options of in vivo physiology supported quantitative systems models tailored for individual applications like drug fate or malady modeling. This technology may eventually be used for clinical laboratory and anatomic pathology testing.

The MIT engineers next commit to target specific organs including the brain, liver, and gi tissue—to model Parkinson’s illness, Digital Trends rumored.

As attention suppliers and medical laboratories adopt preciseness drugs, MIT’s contributions square measure each timely and vital. the flexibility to accommodate many various configurations in one platform is spectacular, and one thing Dark Daily has been anticipating.

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